Non-canonical amino acids

Unlocking new chemistries, structures, and functions beyond nature's 20 amino acid palette

Biology gives you 20 building blocks.
We give you hundreds more.

Stability. Permeability. Conjugation handles. Protease resistance.
Properties you can't get from nature.

Examples from recent scientific breakthroughs (2024-2025)

Boost stability & immunogenicity

Cell permeability

New-to-nature geometries

Precise bioconjugation

Molecule activation

Enhanced catalytic activity

Complete biosynthesis

Protease resistance

Modular bispecifics

Dynamic activity control

Fine-tuned acid-base switch

Quinoline heterocycles

Heteropolymer backbone

Enhanced ADC linkers

Architecture

Prolonged action

Catalysis

Functional switch

Activity, stability, structure

Stable functional modifications

De novo protein synthesis study

Selectivity, PK, activation

Superior activity and low tox

Stability, binding