Our platform
A comprehensive technology platform combining synthetic genomics with engineered translation for creating programmable biomolecules at unprecedented scale.
Reprogramming cellular biofactories
Transform natural cells into programmable biofactories with expanded chemical capabilities.
Synthetic genomics
World-leading capability in whole genome synthesis. We design and build entire genomes from scratch, creating organisms with fundamentally new properties.
- De-novo genome design
- Codon compression & optimization
- Syn61 chassis development
- Genome-scale engineering
Engineered translation
Expanded genetic code incorporating non-canonical amino acids. Biosynthesis of programmable polymers with precisely defined sequences.
- Non-canonical amino acid incorporation
- Expanded genetic code
- Sequence-defined biopolymers
- Site-specific modifications
Genetic code expansion
From synthetic genome to functionalised proteins with non-canonical amino acids
Platform advantages
Enabling next-generation solutions
Creating valuable new-to-nature molecules through reprogramming complex biology in a sustainable, scalable and cost-effective way.
Writing recoded genomes
New cellular chemistry
Bioprocess with expanded cellular chemistries
Design of novel valuable molecules
Our Mission
To revolutionise the production of exotic and complex molecules by bridging the gap between biology and organic chemistry, enabling sustainable, scalable, and cost-effective solutions for a wide range of applications.
Our Vision
To become the programmable biomolecule company driving innovation and sustainability in an efficient, fast and cost-effective way.
Frequently Asked Questions
What is genetic code expansion and how does Constructive.bio use it?
Genetic code expansion reassigns codons in an organism's genome so that the ribosome incorporates non-canonical amino acids (ncAAs) during translation. Constructive.bio uses whole-genome-recoded Syn61 E. coli with freed sense codons and engineered aminoacyl-tRNA synthetase/tRNA pairs to incorporate over 300 ncAAs site-specifically into peptides and proteins.
What is Syn61 and why is it important for peptide manufacturing?
Syn61 is Constructive.bio's whole-genome-recoded E. coli strain in which specific sense codons have been reassigned across all ~4 million base pairs. Unlike amber suppression, which competes with natural termination, Syn61 provides dedicated codons for ncAAs — enabling high-fidelity, multi-site incorporation without compromising cell viability or yield.
How many non-canonical amino acids can be incorporated into a single peptide?
Constructive.bio's platform can incorporate up to three different non-canonical amino acids in a single peptide, each at defined positions. This includes functional handles for click chemistry conjugation, backbone modifications for protease resistance, and lipophilic residues for half-life extension.
What is amber suppression and how does Constructive.bio's approach differ?
Amber suppression uses the UAG stop codon to encode a single ncAA, but competes with release factor 1 (RF1) for termination, limiting efficiency and restricting incorporation to one ncAA type. Constructive.bio reassigns sense codons in a fully recoded genome, eliminating competition and enabling multiple orthogonal ncAAs in one molecule at high fidelity.
What types of peptide therapeutics does the platform enable?
The platform supports nine therapeutic modalities: GLP-1 peptides, antibody-drug conjugates (ADCs), oral peptides, optimised peptides, interleukins and cytokines, VHH nanobodies, immunocytokines, covalent biologics, and vaccine conjugates. Each leverages ncAA incorporation for properties unachievable with the 20 natural amino acids.
Interested in our platform?
Let's discuss how our technology can accelerate your research and development.
Get in Touch →