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Rewriting biology to change lives

Our platform

A comprehensive technology platform combining synthetic genomics with engineered translation for creating programmable biomolecules at unprecedented scale.

Reprogramming cellular biofactories

Transform natural cells into programmable biofactories with expanded chemical capabilities.

Natural cell vs Constructive.bio reprogrammed cellular biofactory
Synthetic genomics

Synthetic genomics

World-leading capability in whole genome synthesis. We design and build entire genomes from scratch, creating organisms with fundamentally new properties.

  • De-novo genome design
  • Codon compression & optimization
  • Syn61 chassis development
  • Genome-scale engineering
Engineered translation

Engineered translation

Expanded genetic code incorporating non-canonical amino acids. Biosynthesis of programmable polymers with precisely defined sequences.

  • Non-canonical amino acid incorporation
  • Expanded genetic code
  • Sequence-defined biopolymers
  • Site-specific modifications

Go deeper

The genome synthesis revolution

A four-step guide to whole-genome synthesis (design, build, assemble, test) for megabase-scale synthetic DNA enabling recoded organisms.

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Genetic code expansion

From synthetic genome to functionalised proteins with non-canonical amino acids

Genetic code expansion process showing ncAA incorporation via orthogonal tRNA and ribosome
4M+
Base pairs in Syn61
Largest synthetic genome
18,214
Codon replacements
Systematic recoding
Hundreds
ncAAs available
Diverse chemistries

Go deeper

Reprogramming life: how genetic code expansion will redefine the bioeconomy

How compressing E. coli's genetic code from 64 to 57 codons frees triplet codons for non-canonical amino acids, enabling fermentation-based production of peptide therapeutics.

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Platform advantages

Fidelity, Flexibility, Scalability - Three circles showing platform advantages
Applications

Enabling next-generation solutions

Creating valuable new-to-nature molecules through reprogramming complex biology in a sustainable, scalable and cost-effective way.

Writing recoded genomes

New cellular chemistry

Bioprocess with expanded cellular chemistries

Design of novel valuable molecules

Our Mission

To revolutionise the production of exotic and complex molecules by bridging the gap between biology and organic chemistry, enabling sustainable, scalable, and cost-effective solutions for a wide range of applications.

Our Vision

To become the programmable biomolecule company driving innovation and sustainability in an efficient, fast and cost-effective way.

Interested in our platform?

Let's discuss how our technology can accelerate your research and development.

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