Two pillars
Our platform rests on two foundational technologies that together enable unprecedented control over biological systems.
World's most advanced genome synthesis platform
World's largest synthetic organisms (base pairs)
3x faster
Only Constructive Bio can write genomes from scratch and recode entire organisms
World's most advanced translation machinery engineering
Chemical space for protein building blocks
20 canonical
amino acids
3 additional slots
hundreds of chemistries
Only Constructive Bio can incorporate multiple ncAAs into a single molecule
Synthetic genomics
We design and build entire genomes from scratch, creating organisms with fundamentally new properties.
Our Syn61 strain represents the cutting edge of synthetic biology - a completely synthetic E. coli genome with a compressed genetic code.
De-novo genome design
Complete freedom to design genomes with any desired properties
Codon compression
Freeing up codons for new functions by systematic genome-wide recoding
Syn61 chassis
World's first organism with a fully synthetic, compressed genome
Genome-scale engineering
Making thousands of precise changes across entire genomes
Engineered translation
We expand the genetic code to incorporate non-canonical amino acids at precise positions.
By engineering the translation machinery, we can produce proteins and peptides with chemistries that nature never evolved.
Genetic code expansion
Adding new amino acids to the genetic code
Orthogonal systems
Dedicated tRNA/synthetase pairs for each ncAA
Site-specific incorporation
Precise positioning of ncAAs in any sequence
Multi-ncAA proteins
Multiple different ncAAs in a single molecule
Built on strong IP
Our technology is protected by an extensive patent portfolio covering synthetic genomics and genetic code expansion.
Foundational patents
Core IP from MRC Laboratory of Molecular Biology
Exclusive licenses
Exclusive rights to key enabling technologies
Ongoing innovation
Continuous expansion of our IP portfolio