About us
Pioneering the future of synthetic biology from Cambridge, UK.
Our mission
To revolutionize biotechnology by rewriting the fundamental code of life—enabling the creation of biomolecules and organisms that were previously unimaginable.
Founded on decades of pioneering research at the MRC Laboratory of Molecular Biology, Constructive.Bio is translating breakthrough science into transformative applications in therapeutics and biomanufacturing.
Prof. Jason Chin
Pioneer of genetic code expansion and synthetic genomics whose groundbreaking research forms the foundation of Constructive.bio's platform.
2019: Created Syn61, the world's first organism with a fully synthetic, radically recoded genome (Nature)
2021: Demonstrated breakthrough genetic code reprogramming enabling viral resistance (Science)
2024: Developed groundbreaking tRNA display method for translation machinery engineering (Nature)
2025: Advanced to 57-codon genetic code, further expanding chemical possibilities (Science)
Published in Nature, Science, and Nature Chemistry with revolutionary discoveries that enable the creation of biomolecules previously thought impossible.
Our journey
Foundational science
Pioneering work on genetic code expansion begins at MRC-LMB
Syn61 published
Publication of the world's first organism with a fully synthetic, radically recoded genome
Seed funding and company launch
Constructive.bio established to commercialize breakthrough technology
Series A funding
Raised $58 million Series A to advance platform development and expand partnerships
EIT Generative Biology Institute
Prof. Jason Chin appointed to lead the Ellison Institute of Technology's new Generative Biology Institute
Pipeline advancement
Multiple programs advancing through development stages
Our investors
