Biology gives you 20 building blocks.
We give you hundreds more.
Stability. Permeability. Conjugation handles. Protease resistance.
Properties you can’t get from nature.
Non-canonical amino acids
ncAAs expand the chemical properties available to peptides and proteins beyond the 20 standard amino acids. Constructive Bio can access hundreds of them for site-specific incorporation by fermentation.
Biology gives you 20 building blocks.
How we engineer novel aminoacyl-tRNA synthetases
We engineer orthogonal aminoacyl-tRNA synthetases (aaRS) that selectively charge non-canonical amino acids onto dedicated tRNAs. These engineered aaRS–tRNA pairs work alongside the cell’s native translation machinery without cross-reacting, enabling site-specific incorporation of ncAAs into peptides and proteins during standard fermentation.
ncAAs in action
Examples from recent scientific breakthroughs (2024-2025)
